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Denocrine or Danazol is an antigonadotropin that is used for treating hormone-related disorder. The hormone related breast-enlargement in men is effectively cured. Now, it is widely used by body builders to get rid of all possible feminisation resulting from aromatizing the steroids. Denocrine has slightly androgenic effect but it has no anabolic effect. It is the derivative of steroid ethisterone that restricts the production of gonadotrophins. Being approved by the Food and Drug administration, Denocrine is used to treat endometriosis. But then, it is used for the amazing masculinising effect that the athletes gain.

Effects on the body
With Denocrine:

  • Ovulation is prevented
  • Suppression of luteinizing effect.
  • Inhibits the ovarian steroidogenesis
  • Decreases the secretion of estradoil
  • Displaces testosterone from SHBG or sex hormone-binding globulin
  • Stimulates progesterone receptors and androgen
  • Builds muscular stamina and improves athletic performance.

Side effects on the body

  • Virilisation symptoms
  • Hot flashes
  • Enhanced libido
  • Perspiration
  • Increase in the liver values
  • Fluid retention leading to higher blood pressure
  • Women using it encounters unwanted hair growth
  • Acne
  • Deepening of the voice
  • Adversely effects the blood lipid profile
  • Elevation of the liver enzyme levels
  • Mood swings
  • Weight gain

How to use
The daily dose of Denocrin should not exceed 400mg. Then, it should not be used for more than 6 months continuously, owing to the side effects.

Expert tips/Precautions

  • Prolonged usage can increase the risk of developing ovarian cancer
  • Patients having endometriosis must avoid Denocrin
  • It can increase the risk of liver tumour and so small dosages are recommended
  • Denocrin must be avoided during pregnancy for it may harm the foetus.
  • Women on Denocrin, should take up contraceptive therapy to avoid being pregnant
  • People with liver diseases should not use it.

Steroids must be taken under doctor prescription.


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